Effective TI Stimulation of the Human Hippocampus and Striatum

We are proud to announce the publication of two papers in the latest issue of Nature Neuroscience resulting from our long-standing collaborative work with the consortia led by Prof. Grossman (Imperial College) and Prof. Hummel (EPFL). The findings in these publications demonstrate for the first time in human subjects the effectiveness of non-invasive temporal interference (TI) stimulation of deep brain regions.


Entitled “Non-Invasive Temporal Interference Electrical Stimulation of The Human Hippocampus” and “Noninvasive Theta Burst Stimulation of The Human Striatum Enhances Striatal Activity and Motor Skill Learning“, these two publications represent an important step towards the adoption of TI stimulation as a promising and effective method for non-invasive modulation of deep brain function with high therapeutic potential.


The targets included the anterior hippocampus and the striatum, where TI stimulation evoked functional and behavioral responses associated with memory performance and motor learning, respectively. Subject-specific in silico modeling was crucial for optimizing the experimental conditions in terms of targeting and focality and for correlating subject-specific exposure with individual responses.

Read more about these two publications on our website: Violante et al. and Wessel et al..